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Non-fatal myocardial infarction Tirzepatide showed a non-significant trend toward reduction in non-fatal MI compared with placebo (HR 0.83, 95% CI 0.651.05), whereas semaglutide was the only agent that achieved a statistically significant reduction (HR 0.78, 95% CI 0.680.91)

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Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial [published correction appears in lancet

doi: 10.1093/ndt/gft022 113