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The following are known triggers of mast cell degranulation (in addition to IgG activation via pathogen or allergen):[ref] Acetylcholine Complement fragments (C3, C4, C5) Various drugs, environmental toxins (MRGPRX2 receptor, details below) Peptides (including endorphin, leptin, PTH, and more) Physical conditions (cold, heat, pressure, stress, and vibration)
this result is consistent with the previous study in APP mice [8]
doi:10.3389/fmicb.2019.00477 Cicenia A, Scirocco A, Carabotti M, et al
Most urine color variations are harmless and result from dietary choices or supplements