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Yang PT, Anastas JN, Toroni RA, Shinohara MM, Goodson JM, Bosserhoff AK et al

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Nonetheless, heavy metal exposure does cause severe morbidity which may result in mortality should it be missed, undiagnosed or managed inadequately

175 Animal research has demonstrated that the melatonin receptor MT2 promotes deep sleep

The authors explicitly frame their own finding as relevant to the injection question: topical application, they note, "may offer an effective alternative to injection," comparing the quantity of copper made bioavailable through a realistic topical patch against a reference subcutaneous injection dose used in animal research