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The prolonging effect in inhibitory signaling by -pinene and 3-carene was fully blocked by flumazenil, suggesting that these two phytoncide components modulate the GABA A BZD receptor with having the same molecular mechanism with diazepam and zolpidem

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These findings are biologically plausible, as both GLP1-RAs and SGLT2i exert pleiotropic effects beyond glycemic control, including improvements in endothelial function and reductions in systemic inflammation, which may counterbalance the prothrombotic milieu associated with type 2 diabetes

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