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3.2.2 Glutathione Peroxidase 4 GPX4 is a selenoprotein enzyme, and its activity is the cornerstone of antioxidant defense (Ursini and Maiorino 2020)

FOXO4-DRI Safety and Side Effects: What the Evidence Shows (2026) In the published mouse studies, FOXO4-DRI caused no reported side effects: treated animals kept their weight, blood counts, and organ markers while senescent cells were cleared, and the peptide spared healthy cells in culture

Researchers found its safety profile was virtually identical to placebo, with no treatment-related serious adverse events reported in any study