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T2DM patients have low bone mineral density and increased fracture risk, especially hip and vertebral fractures ( GLP-1 is produced by the post-translational processing of the glucagon gene in intestinal endocrine cells ( Our study also demonstrated that GLP-RAs could significantly reduce the risk of osteoporosis in T2DM patients, consistent with the find with Liraglutide

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170 Similarly, in myoblasts, knocking down ZIP8 also hampers myotube formation by causing a significant reduction in cellular manganese, iron, zinc, and calcium levels, leading to decreased differentiation and proliferation of myoblasts 171 (Fig

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