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First, lactate binding increases the catalytic activity of LDHB, thereby enhancing the NADH-dependent reduction of CoQ

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However, the precise control of ferroptosis, including its induction, inhibition, and fine-tuning, remains an area of ongoing scientific discourse ( Figure 9 While the impact of ferroptosis on malignant cells has been extensively explored, the reciprocal relationship between ferroptosis and macrophages, critical immune cells that profoundly influence disease trajectory and prognosis, has received comparatively less attention