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Thus, in BD type 1, serotonin reuptake inhibitors (SSRIs) and bupropion associated with lithium, divalproex or an atypical antipsychotic are reasonable options, while serotonin norepinephrine reuptake inhibitors (SNRIs) and monoamine oxidase inhibitors (MAOIs) have a have higher propensity to induce manic switch and to produce mood destabilization

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A miR-130b overexpression plasmid was introduced into HeLa-229 cells via transfection to generate miR-130b-enriched microvesicles (miR-130b-MV), and the secreted MVs, highly enriched in miR-130b, were isolated