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Emerging research on GLP-1 agonists suggests that these medications could benefit more than those who meet strict BMI criteria

Improved ejection fraction, reduced fibrosis, and increased survival

Disproportionality analysis A sequential approach was adopted to systematically address major confounders: (1) An exploratory disproportionality approach comparing GLP-1RAs with all other drugs reported in the FAERS database, using venlafaxine as the positive control and empagliflozin/orlistat as the negative control

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Early prioritization of MC4R as a therapeutic target for obesity was driven by converging genetic and pharmacological evidence demonstrating its primary role in regulating food intake and body weight