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PTH1R has the longest ECL1, but it is unstructured in both LA-PTHPTH1RG s 19 and ePTHPTH1R 37 structures, probably owing to the great mobility of PTH1Rs ECD and specific binding mode, consistent with the mutagenesis studies

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Moreover, TRE, a subtype of IF, has been associated with symptom alleviation in individuals with irritable bowel syndrome (IBS) and improvements in overall gastrointestinal health markers [82]