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This suggests that GLP-1 receptor agonists may confer cardiovascular protection through multiple mechanisms, potentially including anti-inflammatory effects, blood pressure reduction, and vascular benefits, in addition to lipid improvements

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The plSAM plasmid contains a core component named SAM, which consists of the signal peptide (SPusp45), the propeptide (PS), the multiple clone site (MCS), a designed M cell-targeting peptide (Mtp), and the peptidoglycan-binding domain of AcmA (cA domain)

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Real-world weight change, adherence, and discontinuation among patients with type 2 diabetes initiating glucagon-like peptide-1 receptor agonists in the UK