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This results in increased GH synthesis and pulsatile secretion

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But more research is needed to confirm if this is due to the medication or a different cause

Changes in opioid receptor expression, especially MOR, reduce the inhibitory function and efficiency of endogenous opioid peptides when the body responds to nociceptive stimuli, enhances neuronal excitability, and promotes the occurrence of sensory sensitization and the development of NP [81,103]

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