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The partitioning rate in buffer can be considered a measure of the drug's absolute affinity for the RBC-binding sites, while the partitioning rate in plasma indicates the relative drugs affinity for RBC-binding sites with respect to that of the plasma, such as albumin ( i.e., drug molecules that are not bound to albumin or other plasma-binding sites) can partition into RBCs

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Notably, a higher IGF-1 LR3 dosage does not necessarily result in more pronounced effects

Pinto et al., 2010)

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