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Similarly, experimental studies have shown that cocaine administration markedly increased FKBP5 expression in stress-related brain regions, such as the paraventricular nucleus and bed nucleus of the stria terminalis during early withdrawal, implicating a convergent role for FKBP5 dysregulation across substances in stress-related mood vulnerability 74

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When serum B12 is normal but MMA is elevated, this may indicate a functional B12 deficiency and may be treated with high-dose injections of vitamin B12, which help bypass barriers to absorption

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