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Slominski A, Wortsman J, Paus R, Elias PM, Tobin DJ, Feingold KR

Glucagon-like peptide-1 receptor regulation of basal dopamine transporter activity is species-dependent

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This cell death process hinges on three core mechanisms: (1) accumulation of intracellular labile iron, (2) failure of the glutathione (GSH)/glutathione peroxidase 4 (GPX4) antioxidant axis, often via inhibition of System Xc (the cystine/glutamate antiporter), and (3) peroxidation of membrane polyunsaturated fatty acids (PUFAs) (35)