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The epidemiological rate of 35 per 1,000 person-years (3.5%) includes a broad definition that may encompass milder sensory changes as well as true allodynia

A 2021 Nature Aging study by Lee and colleagues examined MOTS-c in the context of aging directly

US patent 2413493, Bitler WP, Flisik AC, Leonard N, "Synthesis of isomer-free benzyl methyl acetoacetic methyl ester", published 31 December 1946, assigned to Kay Fries Chemicals Inc

In general, medications to continue during pregnancy should be Pregnancy Category C or better

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