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Other than a prior study showing that psychological stress increased striatal DA release in the human ventral striatum [64], our findings are the first to document in humans that a drug-induced aversive and stressful state was associated with DA increases in the dorsal striatum

Importantly, persistent activation of NRF2 that is induced pharmacologically in KEAP1-NRF2-intact cancer cells also decreases NEAA synthesis and makes them rely on exogenous NEAAs (LeBoeuf et al

Immunohistochemical analysis also revealed a significant decrease in the hepatic expression of both proapoptotic markers Bax and caspase-3 with significant increase in antiapoptotic Bcl-2 expression in rats treated with NTZ-200, NAC or 4-PBA when compared to MTX group (Figure 9)

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