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A person is not going to lose half of their body weight and sustain it, and the risks of doing that probably outweigh the benefits. However, percentages tend to take your whole health situation into account (e.g., hormonal life stage, health conditions, etc.) and research shows that losing certain percentages of weightnot a magic numbercan benefit your health

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Originally developed to help manage type 2 diabetes by regulating blood sugar and improving insulin response, semaglutide has also shown significant benefits in weight managementa growing area of focus in aesthetic medicine

TB-500 doesn't have a meaningful evidence base for gastrointestinal use

Most people experience rebound weight gain when they stop taking the drugs, and repeated yo yo effect can leave people feeling depressed