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Contrast laboratory results with real-world outcomes and limitations Lab effects dont necessarily translate into clinical benefit

Intervention with the DPP-4 inhibitor vildagliptin inhibited the Beclin-1-Bcl-2 interaction and enhanced both LC3-II protein and autophagosomes in the non-infarcted region in OLETF rats without normalization of either AMPK/ULK-1 or mTOR/S6 signaling

For example, rats treated with the benzodiazepine antagonist flumazenil along with a benzodiazepine do not develop tolerance but still apparently experience an anxiolytic effect

doi: 10.1016/j.numecd.2014.10.007 16 WolfeF.ClauwD

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