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but considering that maternal meiosis in a female starts during embryogenesis, the contribution of the maternal grandmother's folate intake is still a matter of debate (Copped, Furthermore, overexpression of folate pathway genes mapping to chromosome 21 in a developing DS embryo could result in a different requirement of dietary folates with respect to a normal embryo and, if not properly provided by the maternal diet, could contribute to death in utero , impaired growth and, if the birth is reached, to epigenetic changes of several genes likely contributing to the onset of either congenital defects or other diseases in adult-life (Martnez-Fras et al., 2006)
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