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Consistent dietary changes that feed the microbiome and produce shortchain fatty acids can raise endogenous GLP1 and improve appetite and glucose control

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Eli Lillys R&D spend on its incretin program (which includes tirzepatide, retatrutide, and orforglipron) has been roughly to billion over the last decade

For most researchers focused on weight management, the priority order is: adherence first, side effect management second, appetite alignment third