Chung KT, Lu Z, Chou MW
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However, these peripheral effects do not translate into increased food intake or body weight within 24 h following GLP-1 receptor blockade.43,44 Collectively, these findings support the notion that brain GLP-1 receptors regulate feeding behavior and body weight,3,20,24 complementing the limited phagocytosis of endogenous GLP-1 via peripheral receptors.45 Given the rapid degradation of endogenous GLP-1 upon entering circulation, hypothalamic GLP-1 receptors are likely predominantly activated by GLP-1 neurons originating in the NTS.32 Importantly, recently developed long-acting GLP-1 analogs have been demonstrated to target multiple brain nuclei, including the hypothalamus, thereby expanding the therapeutic potential of GLP-1-based interventions36,46 (See Figure 1)
The body tends to accumulate more weight due to the protein "leverage effect." This means that if the menopausal womans diet lacks sufficient protein, the body tries to compensate by driving her to eat more calories, leading to weight gain
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