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Body weight, metabolic status, and concurrent medicationsparticularly those affecting gastrointestinal motility (such as opioids or anticholinergics) or glucose metabolismcan modify both the intensity and duration of adverse effects

By meta-analysis of the individual cardiovascular endpoints, significant improvements were established for all of the following: myocardial infarction, stroke, cardiovascular mortality, all-cause mortality and hospitalisation for heart failure

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Journal of Clinical Pharmacology, 55(5): 497-504