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Although there is no evidence showing this link, we could speculate that inflammation of the gut could trigger inflammation all the way to the scalp

Deficiencies in vitamin D, vitamin B12, or other micronutrients may contribute to muscle weakness or discomfort

Most patients lose 15 to 20% of body weight over 6 to 12 months

However, in a large study involving people with diabetes who had no comorbidities, GLP-1 RAs were not shown to increase the risk of developing pancreatitis at any time point up through 5 years of use.[ref][ref][ref][ref] The Cleveland Clinic now counsels that GLP-1 RA patients should be screened for pancreatitis risk factors, and a lower dose should be used to reduce the risk of pancreatitis.[ref] Related article : Pancreatitis and Genetic Risk Factors Gastroparesis: Case reports tie semaglutide to a risk of gastroparesis (very slow stomach emptying)

Here is a quick reference table based on common starting weights, assuming moderate activity and a 500-calorie deficit