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74 Mice exposed to cigarette smoke for 8 weeks and treated with hydrogen-rich pure water showed lower lung compliance, decreased levels of oxidative DNA damage markers such as phosphorylated histone H2AX and 8-hydroxy-20-deoxyguanosine, and lower lung senescence markers such as cyclin-dependent kinase inhibitor 2A, cyclin-dependent kinase inhibitor 1, and b-galactosidase

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