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The piperidine ring (yellow) proved optimal in structure-activity relationship (SAR) studies, although other 6-membered rings (e.g., piperazine, cyclohexane) also demonstrated GLP-1R agonism

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Similarly, a Phase II clinical trial assessing PX-12 in patients with previously treated advanced pancreatic cancer was terminated due to a lack of notable clinical efficacy [230]

Some of the pigmented fungi are non-dermatophytes and may represent a therapeutic challenge likely to be surmounted only if the pathogen is known