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In addition to this, the reactive doxorubicin semiquinone radical can be recycled back to doxorubicin, generating an O 2 - superoxide that leads to reactive H 2 O 2 formation, which is neutralised into H 2 O by the conversion of reduced glutathione (GSH) into its oxidised form (GSSG)

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243,244 Nucleobase modification Nucleobases are essential components of nucleic acids, and changes to their structure can affect the stability, biological activity, and immunogenicity of nucleic acids

Compared to normal B vitamins, methylated B vitamins are more effectively absorbed