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Stud Health Technol Inform 192:827831 Winnenburg R, Bodenreider O (2014) A framework for assessing the consistency of drug classes across sources

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While density for the N-terminal lipidation was not visible in the lower resolution cryo-EM map of the repeat Cagri-CTR-Gs complex ( N = 2), the outward rotamer of H296 ECL2 was observed, congruent with similar interactions between the N-terminal acylation and ECL2

In the technical scheme of the invention, Fmoc-Gly-OH is coupled to solid-phase resin of an ionic liquid Linker in the step (2), and the coupling of amino acid is specifically carried out by adopting Fmoc-Gly-OH and the solid-phase resin containing the ionic liquid Linker