Also, thanks to its oncogenic role, the increase in the expression of the LncRNA TUG1 (taurine-upregulated gene 1) is accompanied by the increase in the expression of the mRNAs of HK-II and PKM2 in HL60 cells resistant to doxorubicin (HL60/DOX) ( Particularly in K562 cells, the expression level of miR-18a-5p in DOX-resistant cells is lower compared to K562 cells and normal lymphocytes, and strikingly, miR-18a-5p can inhibit the expression of HIF-1 and, in turn, induce a reduction in the production of pyruvate, ATP and affect the expression of GLUT1, HK-II, PKM2, and lactate dehydrogenase A (LDHA) (Wu et al., 2021)
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