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Ibuprofen, in particular, possesses Nf-kB inhibitory activity that may further help reducing excess inflammation/cytokine release in COVID-19 patients ( there is no evidence supporting the association between Ibuprofen and increased risk of severity of COVID-19 , a position strengthened by a systematic review appeared 2 months later ( Several studies are accumulating and reappraising the importance of NSAIDs in COVID-19 management ( in silico screenings independently identified the COX-II inhibitor celecoxib as a potential anti-SARS-CoV-2 drug, and a very recent study still under peer review reports its beneficial effects plus famotidine in hospitalized patients ( Despite this accumulating evidence, paracetamol (PAC) was suggested as a safer and recommendable alternative for the early and domiciliary management of pain and fever in COVID-19 patients

While the exact location of the neurological injury has yet to be identified since MRI (0.5 T) assessments conducted in 1993 on 2 konzo-affected individuals reported no pathological findings, the phenotypic presentation of various severities (Stages 13) of hyperreflexia and non-spastic paraparesis suggests damage of motor neurons and corresponding brain regions

E.BerkM.MohebbiM.LoughmanA.McGuinnessA

N-acetylcysteine (NAC): impacts on human health

PLoS ONE 13:e0192682