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Two-way ANOVA detected significance in the main effect of exposure (home cage vs novel environment, p = 5.8 10 9 , F (1,31) = 63.087) and genotype ( p = 9.3 10 13 , F (1,31) = 133.291) and interaction between them ( p = 0.0017, F (1,31) = 11.797)

Nonetheless, for new GLP-1 drugs in development, it is imperative to evaluate potential drug interactions since this drug class can alter the efficacy of concomitant medications or increase the risk of adverse events as a result of higher exposure to a co-administrated drug