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Typical B12 Injection Protocol: What You Can Expect If you are a candidate for B12 treatments, you will typically receive a combination of the vitamin mixed with a local anesthetic such as lidocaine

28 However, oral therapy does not improve serum methylmalonic acid levels as well as intramuscular therapy, although the clinical relevance is unclear

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The outer thigh, midway between the hip and the knee, is a reliable subcutaneous injection site and is the preferred alternative when the abdomen is uncomfortable or if site rotation requires a break from abdominal injections