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To mitigate IGF-1 side effects such as joint pain, swelling, and nerve compression, bodybuilders can follow several strategies: use the lowest effective dose under medical supervision, rotate injection sites, maintain proper hydration, support joints with supplements like glucosamine or omega-3 fatty acids, and incorporate stretching and mobility exercises
DOX dramatically reduced IGF-1 abundance by 70% compared to control, consistent with its catabolic effects
[Abstract]2025 Jun 11;33(6):941-956.e10
[DOI] [PubMed] [Google Scholar] 85.Nagaya N., Uematsu M., Kojima M., Ikeda Y., Yoshihara F., Shimizu W., Hosoda H., Hirota Y., Ishida H., Mori H., et al
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