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It is important to recognise that marketing claims linking B12 supplementation directly to weight loss are not supported by robust clinical evidence from UK or international health authorities

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Use should be combined with a reduced-calorie diet and increased physical activity

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A 2006 study in the Journal of Clinical Endocrinology & Metabolism demonstrated that CJC-1295 with DAC produced dose-dependent increases in IGF-1 and GH over extended periods with a favorable tolerability profile