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Expert opinion on optimising type 2 diabetes treatment using fixed-ratio combination of basal insulin and GLP-1 RA for treatment intensification and simplification

Aronne LJ, Horn DB, le Roux CW, et al

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While such compounds have been described, none have yet been considered credible pharmacological candidates (253, 254) due to a combination of factors, including insufficient potency, lack of specificity of binding to the GLP-1R and suboptimal half-life