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These modifications were designed to retain certain beneficial properties while potentially reducing unwanted effects

This transporter effectively imports oxidized glutathione (GSSG) into the ER while exporting the reduced variant (GSH), thereby fine-tuning the oxidative ratio inside the lumen

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One potential role for GSH in the ER could be to reduce non-native disulphide bonds that form in proteins either as the result of oxidative stress or by enzyme-catalysed oxidation