It is often overexpressed in fibrotic lung disease, allergic airway disease, and in the stroma of several cancers (breast, colon, prostate, etc.), where it supports fibrosis, invasion, and metastasis
Weight loss itself can affect how some DOACs are distributed and dosed, particularly in patients who lose significant amounts of weight over a short period
This can be done to lessen curvature with a secondary hope of allowing for better blood flow distal to the plaque, which may improve erections
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On the opposite end, you have influencers and self-proclaimed longevity experts recommending tiny doses, as low as 0.1 mg, claiming they improve gut function or extend lifespan