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When Ozempic (semaglutide) was approved by the FDA in 2017, doctors quickly realized that diabetic patients who took the drug also lost weight

Similarly, activating the Nrf2/HO-1 axis to enhance cellular antioxidant gene expression can hamper ferroptosis, although the potentially excessive iron release from high HO-1 expression must be considered (128)

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Biochemistry of oxidative stress