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The CRL also requested additional technical data on the final commercial product, which Orexo said was unexpected. The FDA previously rejected OX124 in April 2023, citing technical issues with the equipment used for the secondary packaging process. July 10 Product: Novo Nordisks insulin icodec Indication: Diabetes mellitus Novo Nordisk was hit with a rejection Wednesday for its once-weekly basal insulin icodec injection for the treatment of diabetes mellitus

doi: 10.1038/nature25500 102 PontarolloGKollarBMannAKhuuMPKiouptsiKBayerFet al

The membranes were blocked with 5% nonfat dry milk in PBS supplemented with 0.1% (v/v) Tween 20 and incubated overnight at 4C with anti-CPT2, PPAR (Santa Cruz Biotechnology,United States), CPT1A, LCAD, Very long-chain acyl-CoA dehydrogenase (VLCAD), (Proteintech, United States), GAPDH (from Cell Signaling Technology, United States)

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