There is no official contraindication to taking these medications together, and no direct pharmacological interaction has been established between semaglutide and bupropion
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10.1016/j.trsl.2019.07.01010.1016/j.ijpharm.2021.120346 [DOI] [Google Scholar] dAvanzo N., Torrieri G., Figueiredo P., Celia C., Paolino D., Correia A., et al
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Helps prevent new fat accumulation (lipogenesis inhibition)