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MC5R is expressed in exocrine glands (sebaceous, lacrimal, harderian) and participates in sebum production and grooming in rodents

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Oral administration of US FDA approved DPP-4 inhibitors, such as Saxagliptin, Vildagliptin, Anagliptin, etc., prolongs the half-lives and thus the action of GLP-1 and GIP, which in turn improves glycemic control with minimal risk of hypoglycemia (Havale and Pal, 2009)

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