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Triggers include: Genetics (most common) Dry or sensitive skin Atopic tendencies Climate changes and winter dryness Because it is rooted in keratin plugging hair follicles , KP responds best to treatments that target the hair follicle itself not acne medicines

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Notably, S-acylation of cysteine residues is known to promote membrane association and proteinprotein interaction (reviewed in Li and Qi, Figure 8)