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51 Dopamine agonists (Table 3) are effective in managing chronic persistent RLS, defined as symptoms occurring at least twice weekly and causing moderate to severe distress, thus justifying consideration of daily therapy

Protocol restraint: Researchers can focus on timing and consistency instead of assuming that escalating the amount will always improve the signal

Saffron has a long history of traditional use as a medicinal agent in addition to being a food coloring and aromatic spice

However, based on absorption rates, there is a significant difference between 2.6 g and 10 g which would result in 1.0 and 1.5 g absorbed per dose, respectively