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In terms of the primary outcome of reduction in A1C from baseline, although the 3-mg oral semaglutide group did not demonstrate superiority to sitagliptin 100 mg at 26 weeks, the 7-mg and 14-mg dosage groups did demonstrate statistically significant reductions in A1C from baseline when compared with sitagliptin

GLP-1 receptor agonists, in particular, may lead to disproportionate loss of lean mass, especially in older adults (129)

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Zhang Y, Fu Y, Jiang T, Liu B, Sun H, Zhang Y, et al