melanotic mucosa Melanosis Coli Melanosis coli: A comprehensive review

Domenech J, Villacorta A, Ferrer JF, Llorens-Chiralt R, Marcos R, Hernndez A, et al

Data were log 10 transformed if they were non-normally distributed and/or heteroscedastic

Preclinical studies indicate potential roles in: Supporting healthy fat metabolism and reduction of adipogenesis Improving insulin sensitivity in metabolic research models Enhancing NAD+ salvage pathway efficiency Exploring effects on energy homeostasis and longevity pathways These findings remain preliminary and confined to laboratory and animal models

Human clinical data remains limited

The many roles of natural insulin-like growth factor-1, including stimulation of cell reproduction and increasing cell longevity, might make it a carcinogen