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The average body mass index when they enrolled in the study was 37 kg/m 2 , which is considered obesity
That can take time, though
This finding is in agreement with previous studies demonstrating that higher adiposity and insulin resistance can influence ghrelin levels ( 8 )
The deletion or inactivation of Parkin down-regulates PGC-1, which in turn leads to the selective degeneration of dopamine neurons in the substantia nigra pars compacta (SNpc)
This effect occurred before any weight loss happened, confirming it was a direct pharmacological action, not a secondary consequence of losing weight
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