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Moreover, the treatment with lobeglitazone restored TGF-1-induced loss of E-cadherin, as observed using immunocytochemistry, and suppressed TGF-1-induced MMP-2 expression and phosphorylation of p38 MAPK, but not ERK1/2 (Jin et al., 2021)

Excessive iron in the internal environment can cause ferroptosis in ovarian GCs, which slows oocyte maturation and follicle development, increasing the risk of infertility (106, 107)