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While transdermal patch delivery systems are under investigation, all commercially available GLP-1 therapies require subcutaneous injection (semaglutide, liraglutide, dulaglutide, tirzepatide) or oral administration (Rybelsus)

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There is a gradient of reactive morphotypes, with the most reactive cells (border-forming astrocytes and amoeboid microglia) concentrating at the lesion perimeter, or even entering (reactive microglia) the lesion core

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