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The REDEFINE protocol escalated the dose over 16 weeks (0.25 0.5 1.0 1.7 2.4 mg), so the full pharmacologic dose was not reached until roughly week 17

Molecular mechanisms of hepatoprotective effect of tectorigenin against anit-induced cholestatic liver injury: role of fxr and nrf2 pathways

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42 For example, extract of sulforaphane, a sulfur-rich compound found in broccoli, has been shown to increase nuclear factor erythroid-2-related factor 2 (Nrf2) and its regulated antioxidants in upper airways, and to improve the ability of macrophages to remove bacteria