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Consequently, although GLP-1RAs hold considerable promise for RA treatment, their clinical translation is constrained by both unresolved mechanistic questions and systemic administration failing to achieve therapeutic intra-articular concentrations constrain their application

Primarily, the CYP3A4 and CYP1A2 are responsible for AF biotransformation, and mainly the exo isomer is formed, which has a highly electrophilic nature, perfect for spontaneous reactions with biological amines in nucleic acids and proteins (Rushing and Selim, 2019)

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10.1016/j.nurt.2008.10.036 159 WalkerK